{"product_id":"cst-88228s","title":"CST,  88228S, Integrin alpha2 Antibody","description":"Polyclonal Antibody for studying Integrin-alpha-2. Validated for Western Blotting. Highly specific and rigorously validated in-house, Integrin alpha2 Antibody (CST #88228) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIntegrin alpha2 Antibody recognizes endogenous levels of total integrin α2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly545 of human integrin α2 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nIntegrins are α\/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2). Integrin alpha-2, also known as cluster of differentiation 49b, forms a heterodimer with integrin beta-1. This integral membrane receptor complex interacts with extracellular matrix molecules laminin, collagen, collagen C-propeptides, fibronectin, and E-cadherin (3-6). It can also act as a receptor for viral pathogens (7,8). Integrin alpha-2\/beta-1 is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, and force generation and organization of newly synthesized extracellular matrix (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nalpha 2 subunit of VLA-2 receptor; BR; CD49 antigen-like family member B; CD49B; Collagen receptor; GPIa; HPA-5; human platelet alloantigen system 5; integrin alpha 2; Integrin alpha-2; integrin subunit alpha 2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); ITA2; ITGA2; platelet antigen Br; platelet glycoprotein GPIa; platelet glycoprotein Ia; Platelet membrane glycoprotein Ia; very late activation protein 2 receptor, alpha-2 subunit; VLA-2; VLA-2 subunit alpha; VLAA2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 170\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46799979348137,"sku":"88228S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-88228s","provider":"Iright","version":"1.0","type":"link"}