{"product_id":"cst-88244s","title":"CST,  88244S, Rab35 (E6B2S) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Rab35. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Rab35 (E6B2S) Rabbit Monoclonal Antibody (CST #88244) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nRab35 (E6B2S) Rabbit Monoclonal Antibody recognizes endogenous levels of total Rab35 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp124 of human Rab35 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nRab35 belongs to the small GTPase superfamily. By interacting with its specific GEF or GAP, Rab35 regulates cargo-specific endocytosis at the vesicle recycling step or mediates exocytosis at the exosome docking\/tethering step (1-4). During cytokinesis, Rab35 interacts with OCRL phosphatase and is essential for maintaining intercellular bridge stability and abscission by controlling the concentration of phosphatidylinositol 4,5-bisphosphate (PIP2) and SEPT2 localization at the intercellular bridge (5,6). Rab35 also plays a role in actin assembly and the recruitment of Cdc42 and Rac1 to the site of filopodium by its direct interaction with actin-bundling protein fascin and actin-binding protein connecdenn 3 (7-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nGTP-binding protein RAY; H-ray; RAB1C; RAB35; RAB35, member RAS oncogene family; Ras-related protein Rab-1C; ras-related protein rab-1c (GTP-binding protein ray); Ras-related protein Rab-35; RAY\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 24\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799979708585,"sku":"88244S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-88244s","provider":"Iright","version":"1.0","type":"link"}