{"product_id":"cst-88314s","title":"CST,  88314S, C\/EBP beta (E2K1U) Rabbit Monoclonal Antibody (Alexa Fluor® 594 Conjugate)","description":"Monoclonal Antibody for studying C\/EBP-beta. Validated for Flow Cytometry (Fixed\/Permeabilized). Highly specific and rigorously validated in-house, C\/EBP beta (E2K1U) Rabbit Monoclonal Antibody (Alexa Fluor\u003csup\u003e®\u003c\/sup\u003e 594 Conjugate) (CST #88314) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFlow Cytometry (Fixed\/Permeabilized): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg\/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nC\/EBP beta (E2K1U) Rabbit Monoclonal Antibody (Alexa Fluor\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly67 of human C\/EBPβ protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCCAAT\/enhancer-binding proteins (C\/EBPs) are a family of transcription factors critical for cellular differentiation, terminal functions, and inflammatory response (1). Six members of the family have been characterized (C\/EBPα, -β, -γ, -δ, -ε, and -ζ) and are distributed in a variety of tissues (1). There are two forms of C\/EBPβ, the 38 kDa liver activating protein (LAP) and the 20 kDa liver inhibitory protein (LIP) which may be products of alternative translation. The 38 kDa LAP protein is a transcriptional activator while LIP may act as an inhibitor of C\/EBPβ transcriptional activity (2). Phosphorylation of C\/EBPβ at distinct sites stimulates its transcriptional activity (3-5). Phosphorylation at serine 105 of rat C\/EBPβ, a unique site only present in the rat sequence, seems essential for rat C\/EBPβ activation (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC\/EBP beta; C\/EBP-beta; CCAAT enhancer binding protein beta; CCAAT\/enhancer binding protein (C\/EBP), beta; CCAAT\/enhancer-binding protein beta; CEBPB; CRP2; IL6DBP; interleukin 6-dependent DNA-binding protein; LAP; LIP; Liver activator protein; Liver-enriched inhibitory protein; liver-enriched transcriptional activator protein; MGC32080; NF-IL6; Nuclear factor NF-IL6; nuclear factor of interleukin 6; TCF-5; TCF5; Transcription factor 5; transcription factor C\/EBP beta\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800550985897,"sku":"88314S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-88314s","provider":"Iright","version":"1.0","type":"link"}