{"product_id":"cst-88464s","title":"CST,  88464S, LAMA2 (F4S9K) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying LAMA2. Validated for Western Blotting,Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, LAMA2 (F4S9K) Rabbit Monoclonal Antibody (CST #88464) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunofluorescence (Frozen): 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunofluorescence (Frozen)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nLAMA2 (F4S9K) Rabbit Monoclonal Antibody recognizes endogenous levels of total LAMA2 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1215 of human LAMA2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nLaminins are a family of proteins important for maintaining the cellular basement membrane (BM) structure and function (1). Laminins exist as heterotrimers of alpha (LAMA), beta (LAMB), and gamma (LAMC) chains. Laminins are reported to be involved in multiple biological processes, including cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis (2). LAMA2 is thought to be associated with the development and function of oligodendrocytes, the cortical plate, and the blood-brain barrier during embryonic and postnatal development. Aberrant expression of LAMA2 is associated with disease progression in patients with congenital muscular dystrophy type 1A (MDC1A) (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nLAMA2; Laminin M chain; laminin subunit alpha 2; Laminin subunit alpha-2; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; laminin, alpha 2; LAMM; MDC1A; Merosin heavy chain; mutant laminin subunit alpha 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 344\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799981543593,"sku":"88464S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-88464s","provider":"Iright","version":"1.0","type":"link"}