{"product_id":"cst-88499t","title":"CST,  88499T, PDE12 (E2V7J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PDE12. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PDE12 (E2V7J) Rabbit Monoclonal Antibody (CST #88499) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPDE12 (E2V7J) Rabbit Monoclonal Antibody recognizes endogenous levels of total PDE12 protein. This antibody detects precursor and mature isoforms of PDE12 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PDE12 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\n2',5'-phosphodiesterase 12 (PDE12) is a ubiquitously expressed enzyme localized to the mitochondrial matrix. The catalytic activity of PDE12 is, in part, responsible for degradation of 2',5'-oligoadenylate second messengers (1-4). Through its ability to degrade 2',5'-oligoadenylates, PDE12 is considered to be a negative regulator of the interferon-induced OAS\/RNase L antiviral signaling pathway. Indeed, either inhibition of PDE12 activity or loss of PDE12 expression has been shown to protect cells from viral pathogens by upregulating the activity of the OAS\/RNase L pathway (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n2-PDE; 2'-PDE; 2'-phosphodiesterase; 2',5'-phosphodiesterase 12; Mitochondrial deadenylase; PDE12; phosphodiesterase 12\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 75, 70\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799981772969,"sku":"88499T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-88499t","provider":"Iright","version":"1.0","type":"link"}