{"product_id":"cst-88686t","title":"CST,  88686T, MUC2 (CCP58) Mouse Monoclonal Antibody","description":"Monoclonal Antibody for studying MUC2. Validated for IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, MUC2 (CCP58) Mouse Monoclonal Antibody (CST #88686) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nIHC Leica Bond: 1:800 - 1:3200\nImmunohistochemistry (Paraffin): 1:800 - 1:3200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM PBS containing 0.05% BSA and 0.05% sodium azide. Stable for 36 months when stored at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze\/thaw cycles . A slight precipitate may be present, but will not interfere with antibody performance.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: IHC Leica Bond, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMUC2 (CCP58) Mouse Monoclonal Antibody recognizes endogenous levels of total MUC2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide from human MUC2 protein, coupled to KLH.\n\u003cb\u003eBackground\u003c\/b\u003e\nMucins are a family of large glycoproteins that create the structural component of mucus. Mucus functions as a blockade against pathogenic invasion and physical injury to the respiratory, gastrointestinal, and urogenital tracts (1). Mucins create a protective layer for epithelial cells as either membrane-bound (MUC1, MUC3, MUC16, and MUC17) or secreted (MUC2, MUC5AC, and MUC19) proteins. MUC2, or mucin-2, the main O-glycosylated protein found in mucus, is secreted by goblet cells (2). The structure of MUC2 contains cysteine-rich N- and C-terminal domains along with a protein core made up of heavily O-glycosylated mucin domains. The high levels of O-glycosylation along with disulfide bonding make MUC2 resistant to proteolytic cleavage (3). Mucin expression and glycan structure changes occur in cancers of the intestine and impact the development and progression of these cancers (4). The presence of MUC2 in the mucous layer of the colon helps prevent ulcerative colitis (UC) by inhibiting the invasion of bacteria (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nIntestinal mucin-2; MLP; MUC-2; MUC2; mucin 2, intestinal\/tracheal; mucin 2, oligomeric mucus\/gel-forming; Mucin-2; mucin-like protein; SMUC\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): \u0026gt;250\nSource\/Isotype: Mouse IgG1 kappa","brand":"CST","offers":[{"title":"Default Title","offer_id":46800288415913,"sku":"88686T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-88686t","provider":"Iright","version":"1.0","type":"link"}