{"product_id":"cst-89011t","title":"CST,  89011T, DNA Polymerase beta (F5I2R) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying POLB. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, DNA Polymerase beta (F5I2R) Rabbit Monoclonal Antibody (CST #89011) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDNA Polymerase beta (F5I2R) Rabbit Monoclonal Antibody recognizes endogenous levels of total DNA polymerase β protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn245 of human DNA polymerase β protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nDNA polymerase β ( ) functions in the base excision repair (BER) DNA repair pathway, repairing single-strand DNA breaks (SSBs) arising from oxidative damage, deamination, alkylation, or abasic sites (1). In mitochondria, oxidative stress causes recruitment of DNA polymerase β to repair damaged mitochondrial DNA (mtDNA) (2). DNA polymerase β expression levels and mutations are associated with human cancer (3-6). Inhibition or downregulation of DNA polymerase β is synthetic lethal with defective mismatch repair (MMR) in models of acute lymphoblastic leukemia (ALL) (7) and with deficiency in models of breast cancer (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DNA-directed DNA polymerase beta; DPOLB; MGC125976; POLB; polymerase (DNA directed), beta; polymerase (DNA) beta\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 40\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799988031657,"sku":"89011T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-89011t","provider":"Iright","version":"1.0","type":"link"}