{"product_id":"cst-89194sf","title":"CST,  89194SF, SDF1\/CXCL12 (D8G6H) Rabbit Monoclonal Antibody (BSA and Azide Free)","description":"Monoclonal Antibody for studying SDF-1. Validated for Immunohistochemistry (Paraffin). Highly specific and rigorously validated in-house, SDF1\/CXCL12 (D8G6H) Rabbit Monoclonal Antibody (BSA and Azide Free) (CST #89194) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nThis product is the carrier free version of product #97958. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol. This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT\u0026amp;RUN, or CUT\u0026amp;Tag assays. If you require a carrier-free formulation for chromatin profiling, please contact us . Optimal dilutions\/concentrations should be determined by the end user. BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.\n\u003cb\u003eFormulation\u003c\/b\u003e\nSupplied in 1X PBS (10 mM Na 2 HPO 4 , 3 mM KCl, 2 mM KH 2 PO 4 , and 140 mM NaCl (pH 7.8)). BSA and Azide Free. For standard formulation of this product see product # 97958 .\n\u003cb\u003eStorage\u003c\/b\u003e\nStore at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze\/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSDF1\/CXCL12 (D8G6H) Rabbit Monoclonal Antibody (BSA and Azide Free) recognizes endogenous levels of total SDF1\/CXCL12 protein by immunohistochemistry on paraffin-embedded tissue sections. This antibody recognizes both SDF1\/CXCL12α and SDF1\/CXCL12β.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to human SDF1\/CXCL12 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe stromal cell derived factor 1 (SDF1\/CXCL12) is a small, pro-inflammatory chemoattractant cytokine that regulates leukocyte trafficking through interactions with its cognate 7-transmembrane G protein-coupled receptors (1). The SDF1\/CXCL12 receptor, CXCR4, also serves as a coreceptor for the entry of human immunodeficiency virus into target cells (2). SDF1\/CXCL12 may regulate homing and maintenance of CXCR4-expressing stem or progenitor cells, including embryonic and many somatic stem cells (3,4). Many cancer cells express CXCR4, suggesting that SDF1\/CXCL12 plays a role in cancer metastasis (5,6). Alternative splicing and differential processing during maturation produce a pair of SDF1\/CXCL12 isoforms (SDF1\/CXCL12α and SDF1\/CXCL12β) that have different properties and biological activities (7). Additional isoforms of SDF1\/CXCL12 have been reported (8,9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC-X-C motif chemokine 12; C-X-C motif chemokine ligand 12; chemokine (C-X-C motif) ligand 12; chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1); CXCL12; hIRH; hSDF-1; Intercrine reduced in hepatomas; IRH; PBSF; Pre-B cell growth-stimulating factor; SCYB12; SDF-1; SDF-1-alpha(3-67); SDF-1-beta(3-72); SDF-1a; SDF-1b; SDF1; SDF1A; SDF1B; Stromal cell-derived factor 1; stromal cell-derived factor 1 delta; stromal cell-derived factor 1 gamma; stromal cell-derived factor 1a; TLSF; TLSF-a; TLSF-b; TPAR1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 10\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800288710825,"sku":"89194SF","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-89194sf","provider":"Iright","version":"1.0","type":"link"}