{"product_id":"cst-89495t","title":"CST,  89495T, PFKL (E7G5O) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PFKL. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PFKL (E7G5O) Rabbit Monoclonal Antibody (CST #89495) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPFKL (E7G5O) Rabbit Monoclonal Antibody recognizes endogenous levels of total PFKL protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PFKL protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPhosphofructokinase (PFK) catalyzes the phosphorylation of fructose-6-phosphate in glycolysis (1). There are three isozymes: muscle-type, liver-type, and platelet-type (2). The liver-type PFK (PFKL) is the predominant subunit of PFK found in the liver (1,3). Research studies have shown that because of its location on chromosome 21, this enzyme is overexpressed in Down Syndrome\/trisomy 21 (3,4). PFKL also may have a role in the physiological response to a low fat diet (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n6-phosphofructokinase type B; 6-phosphofructokinase, liver type; ATP-dependent 6-phosphofructokinase, liver type; ATP-PFK; DKFZp686G1648; DKFZp686L2097; FLJ30173; FLJ40909; K6PL; liver phosphofructokinase; liver-type 1-phosphofructokinase; PFK-B; PFK-L; PFKAL; PFKL; Phosphofructo-1-kinase isozyme B; Phosphofructokinase 1; phosphofructokinase, liver; phosphofructokinase, liver type; Phosphohexokinase\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 80\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799990980777,"sku":"89495T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-89495t","provider":"Iright","version":"1.0","type":"link"}