{"product_id":"cst-89661s","title":"CST,  89661S, NCKIPSD (E6Z3N) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying NckIPSD. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, NCKIPSD (E6Z3N) Rabbit Monoclonal Antibody (CST #89661) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNCKIPSD (E6Z3N) Rabbit Monoclonal Antibody recognizes endogenous levels of total NCKIPSD protein. This antibody is expected to recognize isoforms 1 and 3 of NCKIPSD protein. This antibody cross-reacts with a 60 kDa band of unknown origin by western blot in some cell lines.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val716 of human NCKIPSD protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nNCKIPSD (NCK-interacting protein with SH3 domain), also known as SPIN90, is a cytoskeletal adaptor protein involved in organization of the actin cytoskeleton and actin-based cell motility (1). Downregulation of NCKIPSD expression in breast cancer stroma is correlated with decreased survival. NCKIPSD regulates microtubule acetylation in cancer-associated fibroblasts (CAFs) (2). NCKIPSD also plays a role in modulating signaling in the central nervous system (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n54 kDa VacA-interacting protein; 54 kDa vimentin-interacting protein; 90 kDa SH3 protein interacting with Nck; AF3P21; dia interacting protein; Dia-interacting protein 1; diaphanous protein interacting protein; Diaphanous protein-interacting protein; DIP; DIP-1; DIP1; MGC23891; NCK interacting protein with SH3 domain; NCK-interacting protein with SH3 domain; NCKIPSD; ORF1; SH3 adapter protein SPIN90; SH3 protein interacting with Nck, 90 kDa; SPIN90; SPN90; VIP54; WASLBP; WASP-interacting SH3-domain protein; WISH; Wiskott-Aldrich syndrome protein-interacting protein\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 83\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799992225961,"sku":"89661S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-89661s","provider":"Iright","version":"1.0","type":"link"}