{"product_id":"cst-8968t","title":"CST,  8968T, CASK (D24B12) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CASK. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, CASK (D24B12) Rabbit Monoclonal Antibody (CST #8968) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCASK (D24B12) Rabbit Monoclonal Antibody recognizes endogenous levels of total CASK protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu327 of human CASK protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCASK is an adaptor protein with a calcium\/calmodulin-dependent protein kinase domain, an SH3 domain, a guanylate kinase homology domain (GUK), and a PDZ domain. CASK links transmembrane proteins to the cytoskeleton and signaling molecules. In particular, CASK binds to neurexin to stabilize pre- and post-synaptic structures (1). While most CASK protein (~80%) is cytoplasmic, a portion of the protein enters the nucleus, where it acts as a transcriptional coactivator (2). Transgenic mice with CASK insertional mutations die within 24 hours of birth (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCAGH39; calcium\/calmodulin dependent serine protein kinase; calcium\/calmodulin-dependent serin protein kinase; Calcium\/calmodulin-dependent serine protein kinase; calcium\/calmodulin-dependent serine protein kinase (MAGUK family); calcium\/calmodulin-dependent serine protein kinase membrane-associated guanylate kinase; CAMGUK; CASK; CMG; CSKP; FGS4; FLJ22219; FLJ31914; hCASK; LIN2; MICPCH; MRXSNA; Peripheral plasma membrane protein CASK; Protein lin-2 homolog; TNRC8; trinucleotide repeat containing 8\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 105\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799992455337,"sku":"8968T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-8968t","provider":"Iright","version":"1.0","type":"link"}