{"product_id":"cst-8988s","title":"CST,  8988S, DDX6\/RCK (D26C11) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying DDX6. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, DDX6\/RCK (D26C11) Rabbit Monoclonal Antibody (CST #8988) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDDX6\/RCK (D26C11) Rabbit Monoclonal Antibody recognizes endogenous levels of total DDX6\/RCK protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala130 of human DDX6\/RCK protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nDDX6, also known as RCK and p54, was identified as a proto-oncogene product and is a member of the ATP-dependent DEAD box helicase family (1,2). This protein interacts with translation initiation factor eIF4E in the cytoplasmic P-bodies (3) and represses mRNA translation (4). DDX6 is a component of the miRNA induced silencing complex (miRISC) and interacts with Argonaute 1 (Ago1) and Argonaute 2 (Ago2) proteins and (5), functioning in miRNA-mediated translational repression (5). Depletion of DDX6 leads to the disruption of cytoplasmic P-bodies indicating that it is required for P-body formation (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nATP-dependent RNA helicase p54; DDX6; DEAD (Asp-Glu-Ala-Asp) box helicase 6; DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; DEAD box protein 6; DEAD box-6; DEAD-box helicase 6; DEAD\/H (Asp-Glu-Ala-Asp\/His) box polypeptide 6 (RNA helicase, 54kD); FLJ36338; HLR2; IDDILF; Oncogene RCK; P54; Probable ATP-dependent RNA helicase DDX6; RCK; Rck\/p54\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 54\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799993700521,"sku":"8988S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-8988s","provider":"Iright","version":"1.0","type":"link"}