{"product_id":"cst-90204t","title":"CST,  90204T, 4-1BBL\/CD137L\/TNFSF9 (E8W3P) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TNFL9. Validated for Immunoprecipitation,IHC Leica Bond,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, 4-1BBL\/CD137L\/TNFSF9 (E8W3P) Rabbit Monoclonal Antibody (CST #90204) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunoprecipitation: 1:100\nIHC Leica Bond: 1:300 - 1:1200\nImmunohistochemistry (Paraffin): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 26596 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Immunoprecipitation, IHC Leica Bond, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\n4-1BBL\/CD137L\/TNFSF9 (E8W3P) Rabbit Monoclonal Antibody recognizes endogenous levels of total 4-1BBL\/CD137L\/TNFSF9 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human 4-1BBL\/CD137L\/TNFSF9 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTNFRSF9 is a member of the tumor necrosis factor receptor superfamily (1,2). It is also called 4-1BB or CD137 (1, 2). 4-1BB\/CD137\/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5). The ligand 4-1BBL\/CD137L\/TNFSF9 on antigen presenting cells binds to 4-1BB\/CD137\/TNFRSF9 and costimulates the activation of T cells (5). The binding of agonistic antibodies to 4-1BB\/CD137\/TNFRSF9 also leads to costimulation for T cell activation (5). Studies have shown the effectiveness of targeting 4-1BB\/CD137\/TNFRSF9 by its agonistic antibodies in cancer immunotherapy (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n4-1BB ligand; 4-1BB-L; 4-1BBL; CD137L; homolog of mouse 4-1BB-L; receptor 4-1BB ligand; TNF superfamily member 9; TNFL9; TNFSF9; TNLG5A; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; Tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 28\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800248930473,"sku":"90204T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-90204t","provider":"Iright","version":"1.0","type":"link"}