{"product_id":"cst-90426t","title":"CST,  90426T, POR (F6Y3C) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Cytochrome P450 Reductase. Validated for Western Blotting,Immunofluorescence (Frozen),Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, POR (F6Y3C) Rabbit Monoclonal Antibody (CST #90426) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunofluorescence (Frozen): 1:400 - 1:1600\nImmunofluorescence (Immunocytochemistry): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunofluorescence (Frozen), Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPOR (F6Y3C) Rabbit Monoclonal Antibody recognizes endogenous levels of total POR protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human POR protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCytochrome P450 oxidoreductase (POR), also known as CYPOR, is a diflavin reductase that uses flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) as cofactors and nicotinamide adenine dinucleotide phosphate (NADPH) as an electron donor (reviewed in 1). Cytochrome P450 is a family of heme-containing enzymes that function as monooxygenases, oxidizing steroids, fatty acids, drugs, and xenobiotics. These enzymes all depend on POR for electron supply. In addition, POR donates electrons to heme oxygenase, cytochrome b5, and cytochrome c. In addition to its various roles in drug and steroid metabolism, studies have found that POR contributes to lipid peroxidation during ferroptosis (2-4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCPR; CYPOR; cytochrome p450 oxidoreductase; DKFZp686G04235; FLJ26468; NADPH--cytochrome P450 reductase; NADPH--hemoprotein reductase; NADPH-dependent cytochrome P450 reductase; NCPR; P450 (cytochrome) oxidoreductase; P450R; POR\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 78\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799998451881,"sku":"90426T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-90426t","provider":"Iright","version":"1.0","type":"link"}