{"product_id":"cst-90470s","title":"CST,  90470S, HCAR2\/GPR109A (F6D3M) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying GPR109A. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, HCAR2\/GPR109A (F6D3M) Rabbit Monoclonal Antibody (CST #90470) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nHCAR2\/GPR109A (F6D3M) Rabbit Monoclonal Antibody recognizes endogenous levels of total HCAR2\/GPR109A protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human HCAR2\/GPR109A protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nHydroxycarboxylic acid receptor 2 (HCAR2), also known as G protein-coupled receptor 109A (GPR109A), is widely expressed in white and brown adipose tissue, keratinocytes, and various immune cells, including monocytes, macrophages, neutrophils, dendritic cells, and microglia (1,2). HCAR2\/GPR109A has three significant ligands: nicotinic acid (NA), sodium butyrate (SB), and β-hydroxybutyric acid (BHBA) (2,3). HCAR2\/GPR109A activation triggers robust anti-inflammatory effects, leading to anti-atherogenic properties and displaying a role as a potential therapeutic target for treatment of many inflammatory diseases, including neuroinflammatory and\/or neurodegenerative diseases such as those affecting the retina and Alzheimer's disease (2,4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nG protein-coupled receptor 109A; G protein-coupled receptor HM74a; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; G109A; GPR109A; HCA2; HCAR2; HM74A; HM74b; hydroxy-carboxylic acid receptor 2; Hydroxycarboxylic acid receptor 2; Niacin receptor 1; NIACR1; Nicotinic acid receptor; Puma-g; PUMAG\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 45\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46799999434921,"sku":"90470S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-90470s","provider":"Iright","version":"1.0","type":"link"}