{"product_id":"cst-90536s","title":"CST,  90536S, Human IL-17A Recombinant Protein","description":"Growth Factors and Cytokines for studying IL17A in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nHuman IL-17A Recombinant Protein is supplied as lyophilized material that is very stable at -20ºC. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4ºC and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\n\u003cb\u003eBackground\u003c\/b\u003e\nInterleukin-17A (IL-17A) is a cystine-linked homodimeric pro-inflammatory cytokine produced by Th cells, a distinct CD4 T cell lineage (1,2). IL-17A stimulates production of the pro-inflammatory cytokines IL-1β, TNF-α, and IL-6. IL-17A also induces production of the neutrophil chemoattractants IL-8, CXCL1, and CXCL6 thereby bridging adaptive and innate immunity (1,2). IL-17A is intimately involved in mucosal immunity against bacterial infections (1,3) and has a putative role in some autoimmune disorders (1,4). IL-17A effects appear to be exerted primarily through binding to IL-17RA (5). IL-17A binding induces production of cytokines, chemokines, and other proteins through activation of the Erk1\/2 MAP kinase, PI3K\/Akt, p38, and NF-κB pathways (3,4,6). Phosphorylation of some Jaks and Stats has been observed.","brand":"CST","offers":[{"title":"Default Title","offer_id":46800717906089,"sku":"90536S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-90536s","provider":"Iright","version":"1.0","type":"link"}