{"product_id":"cst-90543s","title":"CST,  90543S, Lenalidomide","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nLenalidomide is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.29 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect. Caution: Teratogenic. May cause harm to the unborn child. Avoid all contact with this product during pregnancy.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles .\n\u003cb\u003eBackground\u003c\/b\u003e\nThe immunomodulatory drug Lenalidomide is one of a number of chemically modified analogs of the angiogenesis inhibitor, Thalidomide. Lenalidomide can act as an anti-tumor agent by suppressing angiogenesis and activating the immune system (1). Binding of Lenalidomide to Cereblon (CRBN), a substrate receptor for the CRL4 E3 ubiquitin ligase, causes selective ubiquitination and degradation of the zinc finger transcription factors Ikaros and Aiolos (2). A similar mechanism leads to the ubiquitination and targeted degradation of casein kinase 1α (CK1α) (3). Lenalidomide also downregulates SALL4, a zinc finger transcription factor that has been implicated in some human malformation syndromes, including Duane-radial ray syndrome (Okihiro syndrome) and Acro-renal-ocular syndrome (4). Lenalidomide (and other Thalidomide derivatives) can effectively treat multiple myeloma, mantle cell lymphoma, and non-Hodgkin follicular lymphoma (5-7) and can effectively induce remission in patients with myelodysplastic syndrome, either with or without chromosome 5q deletion (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; CC-5013","brand":"CST","offers":[{"title":"Default Title","offer_id":46800699949225,"sku":"90543S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-90543s","provider":"Iright","version":"1.0","type":"link"}