{"product_id":"cst-90826s","title":"CST,  90826S, Apicidin","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nApicidin is supplied as a lyophilized powder. For a 2 mM stock, reconstitute 1 mg of powder in 801 μl of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nApicidin is a fungal metabolite, broad-spectrum antiprotozoal agent. This small molecule inhibits histone deacetylases (HDACs), known to moderate histone acetylation and chromatin folding during gene expression (1,2). Apicidin has been shown to irreversibly prevent the development of intracellular Apicomplexan parasites through HDAC inhibition (IC = 0.7 nM) (1). Research indicates that Apicidin inhibits tumor cell proliferation through gene expression changes of p21WAF1\/Cip1 and gelsolin, and can cause cell cycle arrest in the G1 phase (2). Apicidin also decreases HIF-1α protein levels in human and mouse cell lines (3). HDAC2 has been recognized as a host immune response to the influenza A virus and several other viruses, making HDAC inhibitors important compounds to study in relation to viral diseases (4,5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCyclo[2S-2-amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-2R-2- piperidinexcarbonyl]","brand":"CST","offers":[{"title":"Default Title","offer_id":46800699981993,"sku":"90826S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-90826s","provider":"Iright","version":"1.0","type":"link"}