{"product_id":"cst-91327s","title":"CST,  91327S, hnRNP C1\/C2 (D6S3N) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying hnRNP C1\/C2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, hnRNP C1\/C2 (D6S3N) Rabbit Monoclonal Antibody (CST #91327) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nhnRNP C1\/C2 (D6S3N) Rabbit Monoclonal Antibody recognizes endogenous levels of total hnRNP C1\/C2 protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile217 of human hnRNP C1\/C2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nHeterogeneous nuclear ribonucleoprotein C1\/C2 (hnRNP C1\/C2) has multiple biological functions including transcriptional regulation, DNA repair, and RNA processing. hnRNP C1\/C2 acts as a ‘molecular ruler' in the mRNA processing pathway, committing nascent transcripts from the chromatin template to the mRNA export pathway once the nascent transcript becomes longer than 200-300 nucleotides (1). hnRNP C1\/C2 associates with SWI\/SNF and NurD family members to form the locus control region (LCR)-associated remodeling complex (LARC), which binds to β-globin gene promoter to prevent transcriptional silencing. Studies indicate that without hnRNP C1\/C2, LARC does not associate with its target DNA sequence (2,3). hnRNP C1\/C2 and other hnRNP family members interact with DNA damage response (DDR) proteins (4). hnRNP proteins regulate double stranded break (DSB) repair by promoting either homologous recombination (HR) or non-homologous end joining (NHEJ) (4). hnRNP C1\/C2 downregulates the expression of miR-21, which leads to the increased expression of programmed cell death 4 (PDCD4) protein in glioblastoma multiforme (GBM) (5). Research studies have shown that silencing of hnRNP C1\/C2 renders GBM cells more susceptible to apoptosis (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC1; C2; heterogeneous nuclear ribonucleoprotein C; heterogeneous nuclear ribonucleoprotein C (C1\/C2); Heterogeneous nuclear ribonucleoproteins C1\/C2; HNRNP; hnRNP C1\/C2; HNRNPC; HNRPC; MGC104306; MGC105117; MGC117353; MGC131677; nuclear ribonucleoprotein particle C1 protein; nuclear ribonucleoprotein particle C2 protein; SNRPC\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 40\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800005628073,"sku":"91327S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-91327s","provider":"Iright","version":"1.0","type":"link"}