{"product_id":"cst-92035c","title":"CST,  92035C, FastScan™ Phospho-IkappaB alpha (Ser32\/36) ELISA Kit","description":"FastScan ELISA Kit for studying IkB-a (Ser32\/Ser36) phosphate in the research area.\n\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: ELISA+\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nThe FastScan™ Phospho-IkappaB alpha (Ser32\/36) ELISA Kit detects endogenous levels of IκBα when phosphorylated at Ser32\/36, as shown in Figure 1. This kit detects proteins from the indicated species, as determined through in-house testing, but may also detect homologous proteins from other species.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eBackground\u003c\/b\u003e\nThe NF-κB\/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB (3-7). IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nEDAID2; I-kappa-B-alpha; IkappaBalpha; IkB-alpha; IKBA; MAD-3; MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappa-B inhibitor alpha; NFKB inhibitor alpha; NFKBI; NFKBIA; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R","brand":"CST","offers":[{"title":"Default Title","offer_id":46800684777641,"sku":"92035C","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-92035c","provider":"Iright","version":"1.0","type":"link"}