{"product_id":"cst-93069s","title":"CST,  93069S, BRDT (E6T6E) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying BRDT. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, BRDT (E6T6E) Rabbit Monoclonal Antibody (CST #93069) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nBRDT (E6T6E) Rabbit Monoclonal Antibody recognizes endogenous levels of total BRDT protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human BRDT protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTestis-specific bromodomain-containing protein (BRDT) is a member of the bromodomains and extra terminal (BET) family of proteins, which also includes BRD2, BRD3, and BRD4 (1-3). BET family proteins contain two tandem bromodomains and an extra terminal (ET) domain, and bind acetyl lysine residues (3). BRDT is expressed in the testes and is essential for male germ cell differentiation, acting as a master regulator of meiotic divisions and post-meiotic genome repackaging (2,4). JQ1 treatment of BRDT has been explored as a potential male contraceptive, as JQ1-treated mice exhibit reduced spermatozoa number and motility without affecting hormone levels (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBRD6; BRDT; bromodomain testis associated; Bromodomain testis-specific protein; bromodomain, testis-specific; Cancer\/testis antigen 9; CT9; RING3-like protein; SPGF21; testis-specific bromodomain protein\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 140\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800023552169,"sku":"93069S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-93069s","provider":"Iright","version":"1.0","type":"link"}