{"product_id":"cst-9321s","title":"CST,  9321S, Phospho-Tyk2 (Tyr1054\/1055) Antibody","description":"Polyclonal Antibody for studying Tyk2 (Tyr1054\/Tyr1055) phosphate. Validated for Western Blotting. Highly specific and rigorously validated in-house, Phospho-Tyk2 (Tyr1054\/1055) Antibody (CST #9321) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPhospho-Tyk2 (Tyr1054\/1055) Antibody detects endogenous levels of Tyk2 protein only when phosphorylated at Tyr1054\/1055. This antibody does not cross-react with Tyk2 protein phosphorylated at other sites.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr1054\/1055 of human Tyk2 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nTyk2 is a member of the Jak family of protein tyrosine kinases. It associates with and is activated by receptors for many cytokines including IL-13, the IL-6 family, IL-10, and IFN-α and β (1-3). Following ligand binding, Tyk2 is activated by phosphorylation of Tyr1054 and\/or Tyr1055 (4). Tyk2 is required for the tyrosine phosphorylation of Stat3 in the IFN-β signaling cascade (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nIMD35; JTK1; Non-receptor tyrosine-protein kinase TYK2; TYK2; tyrosine kinase 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 134\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46800024862889,"sku":"9321S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-9321s","provider":"Iright","version":"1.0","type":"link"}