{"product_id":"cst-93416s","title":"CST,  93416S, PAPD7 (F1Q9R) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PAPD7. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, PAPD7 (F1Q9R) Rabbit Monoclonal Antibody (CST #93416) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPAPD7 (F1Q9R) Rabbit Monoclonal Antibody recognizes endogenous levels of total PAPD7 protein.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His184 of human PAPD7 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPAP-associated domain-containing protein 5 (PAPD5) and PAPD7, also known as TENT4B and TENT4A, respectively, are poly(A) polymerases involved in a layer of mRNA regulation by depositing guanosine residues on the poly(A) tail. This process, called mixed tailing, interferes with the deadenylase CCR4-NOT complex from efficiently deadenylating the poly(A) tail (1). PAPD5 and PAPD7 form a complex with ZCCHC14 and play a role in stabilization of hepatitis RNA (2-4). Small molecule inhibitors of PAPD5 and PAPD7 are being pursued for treatment against hepatitis B by inhibiting their polyadenylase activity (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDNA polymerase kappa; DNA polymerase sigma; LAK-1; LAK1; Non-canonical poly(A) RNA polymerase PAPD7; PAP associated domain containing 7; PAP-associated domain-containing protein 7; PAPD7; POLK; POLS; poly(A) RNA polymerase D7, non-canonical; polymerase (DNA directed) sigma; polymerase (DNA-directed) sigma; TENT4A; Terminal guanylyltransferase; Terminal nucleotidyltransferase 4A; Terminal uridylyltransferase 5; Topoisomerase-related function protein 4-1; TRAMP-like complex polyadenylate polymerase; TRF4; TRF4-1; TRF41; TUTase 5; TUTASE5\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 95\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800026534057,"sku":"93416S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-93416s","provider":"Iright","version":"1.0","type":"link"}