{"product_id":"cst-94127t","title":"CST,  94127T, CD8 beta (D7C8H) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CD8B mouse. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CD8 beta (D7C8H) Rabbit Monoclonal Antibody (CST #94127) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD8 beta (D7C8H) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD8β protein. This antibody detects an 11 kDa band of unknown origin in some cell lines.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with mouse CD8β recombinant protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated α and β subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen-Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8α interacts with the α3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR-antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the α chain recruits the tyrosine kinase Lck, which is essential for T cell activation (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD8 antigen, beta chain 1; Cd8b; Cd8b1; Ly-; Ly-3; Ly-C; Lymphocyte antigen 3; Lyt-; Lyt-3; Lyt3; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-3\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nMW (kDa): 27-32\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800159342761,"sku":"94127T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-94127t","provider":"Iright","version":"1.0","type":"link"}