{"product_id":"cst-94277s","title":"CST,  94277S, INSM1 (F7P8K) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying INSM1. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, INSM1 (F7P8K) Rabbit Monoclonal Antibody (CST #94277) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nINSM1 (F7P8K) Rabbit Monoclonal Antibody recognizes endogenous levels of total INSM1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human INSM1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nInsulinoma-associated protein 1 (INSM1), originally named IA-1, is a zinc-finger protein cloned from an insulinoma and glucagonoma subtraction library (1). It is a transcriptional repressor expressed in the developing pancreas and nervous system and targets genes such as β and insulin, critical regulators of neuroendocrine differentiation during development (2-5). Most importantly, INSM1 has emerged as a key marker in neuroendocrine tumor types, including small cell lung cancer (SCLC), medullary thyroid carcinoma, pheochromocytoma, Merkel cell carcinoma, neuroblastoma, and neuroendocrine tumors of the pancreas, breast, colon, bladder, and prostate (6-9). Some studies have also shown that the level of INSM1 expression may have prognostic value (10,11).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nIA-1; IA1; INSM transcriptional repressor 1; INSM1; insulinoma-associated 1; Insulinoma-associated protein 1; Zinc finger protein IA-1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 63\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800034300073,"sku":"94277S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-94277s","provider":"Iright","version":"1.0","type":"link"}