{"product_id":"cst-94396s","title":"CST,  94396S, KCTD5 Antibody","description":"Polyclonal Antibody for studying KCTD5. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, KCTD5 Antibody (CST #94396) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nKCTD5 Antibody recognizes endogenous levels of total KCTD5 protein. In some cell lines, this antibody also recognizes a 100 kDa band of unknown origin.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg38 of human KCTD5 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nBTB\/POZ domain-containing protein KCTD5 is a member of the potassium channel tetramerization domain family of proteins that play a role in transcriptional repression, cytoskeletal regulation, and ion channel gating (1). KCTD5 interacts with bound ubiquitin proteins and cullin3, and acts as a dependent E3 ligase substrate adaptor through interactions with its BTB domain (2). KCTD5 has been identified as a negative regulator of the AKT pathway by acting as an off switch for G-protein coupled receptor signaling by triggering proteolysis of Gβγ heterodimers dissociated from the Gα subunit (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBTB\/POZ domain-containing protein KCTD5; FLJ20040; KCTD5; potassium channel tetramerisation domain containing 5; potassium channel tetramerization domain containing 5\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 26\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46800036855977,"sku":"94396S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-94396s","provider":"Iright","version":"1.0","type":"link"}