{"product_id":"cst-94475t","title":"CST,  94475T, GRB7 (E7R8V) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying GRB7. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, GRB7 (E7R8V) Rabbit Monoclonal Antibody (CST #94475) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nGRB7 (E7R8V) Rabbit Monoclonal Antibody recognizes endogenous levels of total GRB7 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg29 of human GRB7 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nGRB7 belongs to the GRB7 family of adaptor proteins that mediate cell surface and cytosolic tyrosine kinases to downstream signaling pathways (1-3). The C-terminal SH2 domain of GRB7 has been shown to be important for its interaction with various upstream molecules such as ERBB receptor tyrosine kinases, FAK, EphB1, and SHC. The protein has an RA, CAM-BD, and PH domain located at the central region (GM region) of its sequences to mediate downstream Ras, PI3K\/Akt, ERK, and Calmodulin signaling (3,4). Overexpression of GRB7 promotes cancer proliferation and migration, and disruption of GRB7 function inhibits its effect on cancer growth, invasion, and metastasis (3-5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nB47; Epidermal growth factor receptor GRB-7; GRB7; GRB7 adapter protein; growth factor receptor bound protein 7; Growth factor receptor-bound protein 7\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 62\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800037413033,"sku":"94475T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-94475t","provider":"Iright","version":"1.0","type":"link"}