{"product_id":"cst-95855s","title":"CST,  95855S, COL1A2 Antibody","description":"Polyclonal Antibody for studying COL1A2. Validated for Western Blotting. Highly specific and rigorously validated in-house, COL1A2 Antibody (CST #95855) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCOL1A2 Antibody recognizes endogenous levels of total human COL1A2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn507 of human COL1A2 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nType 1 collagen is the most abundant collagen in many human tissues, including bone, skin, and tendons. It is a trimeric complex comprised of two molecules of COL1A1 (alpha-1 type 1 collagen) and one molecule of COL1A2 (alpha-2 type 1 collagen) (1-3). The loss-of-function mutations in the and genes are a major causative factor for osteogenesis imperfecta (brittle bone disease) (4). Notably, COL1A2 expression levels have also been associated with tumor development in gastric cancer, pancreatic cancer, and chondrosarcoma (5-7). Research studies suggest that upregulation of COL1A2 can generate a modified extracellular matrix environment that promotes cancer cell proliferation, migration, and invasion.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nalpha 2 type I procollagen; alpha 2(I) procollagen; alpha 2(I)-collagen; Alpha-2 type I collagen; CO1A2; COL1A2; Collagen alpha-2(I) chain; collagen I, alpha-2 polypeptide; collagen of skin, tendon and bone, alpha-2 chain; collagen type I alpha 2 chain; collagen, type I, alpha 2; EDSARTH2; EDSCV; epididymis secretory sperm binding protein; OI4; type I procollagen\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 165\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46800051110057,"sku":"95855S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-95855s","provider":"Iright","version":"1.0","type":"link"}