{"product_id":"cst-96692s","title":"CST,  96692S, Entacapone","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nEntacapone is supplied as a lyophilized powder. For a 30 mM stock, reconstitute 10 mg of powder in 1.09 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nEntacapone, also known as OR-611, is a catechol O-methyltransferase (COMT) inhibitor with IC values ranging from 10 nM to 160 nM for rat duodenum and rat liver COMT, respectively (1,2). Taken as an adjuvant with levodopa\/carbidopa therapy, entacapone blocks COMT methylation and subsequent degradation of plasma levodopa, prolonging and improving therapeutic response in Parkinson's patients (3,4). Entacapone inhibition of COMT also works synergistically with (-)-Epigallocatechin-3-gallate (EGCG) to inhibit human and murine lung cancer cell growth (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n2E-2-Cyano-3-34-dihydroxy-5-nitrophenyl-NN-diethyl-2-propenamide; OR-611; OR611","brand":"CST","offers":[{"title":"Default Title","offer_id":46800700342441,"sku":"96692S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-96692s","provider":"Iright","version":"1.0","type":"link"}