{"product_id":"cst-97206t","title":"CST,  97206T, ABCD3 (F2N8W) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ABCD3. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, ABCD3 (F2N8W) Rabbit Monoclonal Antibody (CST #97206) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:50 - 1:250\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nABCD3 (F2N8W) Rabbit mAb recognizes endogenous levels of total ABCD3 protein. This antibody detects a 100 kDa and a 25 kDa protein of unknown identity in some cell lines.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human ABCD3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nATP-binding cassette sub-family D member 3 (ABCD3) is a member of the ABC transporter family, a group of evolutionarily conserved membrane proteins that use ATP hydrolysis to transport diverse substrates across biological membranes (1). ABCD3 was first cloned from rat liver peroxisomes as a 70 kDa peroxisomal membrane protein named PMP70 (2). At the peroxisomal membrane, ABCD3 utilizes a nucleotide-binding domain (NBD) and a transmembrane domain (TMD) to create a cavity that enables transport of its substrates, fatty acyl-CoAs, from the cytosol into the peroxisome for β-oxidation (3). Mutations in the gene have been linked to hepatosplenomegaly (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n70 kDa peroxisomal membrane protein; ABC43; ABCD3; ATP binding cassette subfamily D member 3; ATP-binding cassette sub-family D member 3; ATP-binding cassette, sub-family D (ALD), member 3; CBAS5; dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1)); peroxisomal membrane protein 1 (70kD, Zellweger syndrome); Peroxisomal membrane protein-1 (70kD); PMP70; PXMP1; ZWS2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 70\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800061628585,"sku":"97206T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-97206t","provider":"Iright","version":"1.0","type":"link"}