{"product_id":"cst-97298s","title":"CST,  97298S, CCDC22 (E3F5L) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CCDC22. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CCDC22 (E3F5L) Rabbit Monoclonal Antibody (CST #97298) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCCDC22 (E3F5L) Rabbit Monoclonal Antibody recognizes endogenous levels of total CCDC22 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human CCDC22 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCoiled-coil domain-containing protein 22 (CCDC22) is a highly conserved protein that harbors an N-terminal calponin homology-like (NN-CH) domain and a C-terminal coiled-coil domain. CCDC22 is a core subunit of the COMMD\/CCDC93\/CCDC22 (CCC) protein complex, which also consists of CCDC93 and any one of ten COMMD proteins. The CCC complex, which is a subcomplex of the commander complex, plays a key role in protecting the stability and promoting the endosomal recycling of cell surface transmembrane proteins, such as integrins, LDLR, and the ATP7A copper transporter (1-3). Research studies have also demonstrated that as part of a ubiquitin ligase complex, CCDC22 activates proinflammatory NF-κB signaling by promoting the ubiquitin-dependent degradation of IκB proteins (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCCD22; CCDC22; coiled-coil domain containing 22; Coiled-coil domain-containing protein 22; CXorf37; JM1; RTSC2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 72\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800062775465,"sku":"97298S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-97298s","provider":"Iright","version":"1.0","type":"link"}