{"product_id":"cst-97585t","title":"CST,  97585T, CD11c (D1V9Y) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ITGAX mouse. Validated for WB,IHC,IHC,IF,IF. Available in 3 sizes. Highly specific and rigorously validated in-house, CD11c (D1V9Y) Rabbit Monoclonal Antibody (CST #97585) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nIHC Leica Bond: 1:150 - 1:600\nImmunohistochemistry (Paraffin): 1:150 - 1:600\nImmunofluorescence (Frozen): 1:100 - 1:400\nImmunofluorescence (Immunocytochemistry): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 39143 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, IHC Leica Bond, Immunohistochemistry (Paraffin), Immunofluorescence (Frozen), Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD11c (D1V9Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total CD11c protein. Non-specific staining of the epithelium in fixed frozen mouse intestine was observed by immunofluorescence. Non-specific staining in fixed frozen mouse brain was observed by immunofluorescence.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala1153 of mouse CD11c protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCD11c (integrin αX, ITGAX) is a transmembrane glycoprotein that forms an α\/β heterodimer with CD18 (integrin β2), which interacts with a variety of extracellular matrix molecules and cell surface proteins (1). CD11c is primarily used as a dendritic cell marker. Dendritic cells can be classified into two major types: CD11c+ conventional dendritic cells that specialize in antigen presentation, and CD11c- plasmacytoid dendritic cells that specialize in type I interferon production (2, 3). CD11c expression has also been observed on activated NK cells, subsets of B cells, monocytes, granulocytes, and some B cell malignancies including hairy cell leukemia (4-7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAI449405; CD11 antigen-like family member C; Cd11c; CD11C (p150) alpha polypeptide; complement receptor 4; Cr4; integrin alpha X; Integrin alpha-X; integrin aX; ITAX; Itgax; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95; mFLJ00114; MFLJ00114 protein; N418\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nMW (kDa): 145\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800172122281,"sku":"97585T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-97585t","provider":"Iright","version":"1.0","type":"link"}