{"product_id":"cst-97849t","title":"CST,  97849T, DDX15 (F4H6R) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying DDX15. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, DDX15 (F4H6R) Rabbit Monoclonal Antibody (CST #97849) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDDX15 (F4H6R) Rabbit Monoclonal Antibody recognizes endogenous levels of total DDX15 protein. This antibody detects a 45 kDa band of unknown origin in some cell lines.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human DDX15 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nDEAH-box helicase 15 (DHX15), also known as DEAD-box polypeptide 15 (DDX15), is an RNA helicase involved in mRNA processing and antiviral innate immunity (1-4). It is a ubiquitously expressed protein containing a conserved DEAD (Asp-Glu-Ala-Asp) motif, which is important for ATP hydrolysis and unwinding RNA structures (1-4). DDX15 acts as an important RNA sensor in myeloid dendritic cells and induces the production of type I IFN and proinflammatory cytokines (4,5). In intestinal epithelial cells, DDX15 interacts with NLRP6 to restrict viral infection by triggering NLRP6 inflammasome activation and IL-18 secretion (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nATP-dependent RNA helicase #46; ATP-dependent RNA helicase DHX15; DBP1; DDX15; DEAD\/H (Asp-Glu-Ala-Asp\/His) box polypeptide 15; DEAD\/H box-15; DEAH (Asp-Glu-Ala-His) box helicase 15; DEAH (Asp-Glu-Ala-His) box polypeptide 15; DEAH box protein 15; DEAH-box helicase 15; DHX15; HRH2; Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; PRP43; PRPF43; PrPp43p; Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15; RNA helicase 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 91\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801033953449,"sku":"97849T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-97849t","provider":"Iright","version":"1.0","type":"link"}