{"product_id":"cst-97885t","title":"CST,  97885T, ZEB2 (E6U7Z) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ZEB2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, ZEB2 (E6U7Z) Rabbit Monoclonal Antibody (CST #97885) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nZEB2 (E6U7Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total ZEB2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro722 of human ZEB2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nZEB family proteins are zinc-finger and homeobox domain containing transcription factors. There are two members in mammals, ZEB1 (δ-EF1, TCF8, AREB6) and ZEB2 (SIP1). ZEB1 and ZEB2 contain two separate zinc-finger domains and a homeodomain (1). While ZEB proteins mainly function as transcriptional suppressors, they are able to activate transcription, dependent on DNA-context and cell type (1). One of the targets suppressed by ZEB proteins is E-cadherin. Downregulation of E-cadherin is one of the hallmarks of epithelial mesenchymal transition (EMT), a critical feature of normal embryonic development, which is also utilized by malignant epithelial tumors to spread beyond their origin (2-4). ZEB1 mutations are associated with posterior corneal dystrophy, and ZEB2 mutations were reported to be associated with Hirschsprung (HSCR) disease (5-8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ42816; HSPC082; KIAA0569; SIP-1; SIP1; SMAD interacting protein 1; Smad-interacting protein 1; SMADIP1; ZEB2; ZFHX1B; ZFX1B; zinc finger E-box binding homeobox 2; Zinc finger E-box-binding homeobox 2; zinc finger homeobox 1b; Zinc finger homeobox protein 1b\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 180, 210\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801034182825,"sku":"97885T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-97885t","provider":"Iright","version":"1.0","type":"link"}