{"product_id":"cst-98204t","title":"CST,  98204T, Integrin alpha5 (D7B7G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ITGA5. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Integrin alpha5 (D7B7G) Rabbit Monoclonal Antibody (CST #98204) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIntegrin alpha5 (D7B7G) Rabbit Monoclonal Antibody recognizes endogenous levels of total Integrin α5 protein.\nSpecies Reactivity: Human, Mouse, Rat, Hamster, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly117 of human Integrin α5 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nIntegrins are α\/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2). Integrin α5\/β1 is involved in multiple biological processes including embryonic development, angiogenesis and tumor metastasis (4,5). By interaction with its fibronectin ligand, α5\/β1 transduces signals that regulate cell adhesion, migration, matrix assembly and cytoskeletal organization (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD49 antigen-like family member E; CD49e; Fibronectin receptor subunit alpha; fibronectin receptor, alpha polypeptide; fibronectin receptor, alpha subunit; FNRA; Integrin alpha-5; Integrin alpha-5 heavy chain; Integrin alpha-5 light chain; Integrin alpha-F; integrin subunit alpha 5; integrin, alpha 5 (fibronectin receptor, alpha polypeptide); ITA5; ITGA5; ITGA5\/SLC9B1 fusion; very late activation protein 5, alpha subunit; VLA-5; VLA5A\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Hm Mk\nSENSITIVITY: Endogenous\nMW (kDa): 150\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801035624617,"sku":"98204T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-98204t","provider":"Iright","version":"1.0","type":"link"}