{"product_id":"cst-98245s","title":"CST,  98245S, CD21\/CR2 Antibody","description":"Polyclonal Antibody for studying CR2. Validated for Western Blotting. Highly specific and rigorously validated in-house, CD21\/CR2 Antibody (CST #98245) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCD21\/CR2 Antibody recognizes endogenous levels of total CD21\/CR2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp430 of human CD21\/CR2 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nComplement receptor type 2 (CD21\/CR2) is a type 1 transmembrane glycoprotein whose expression is largely restricted to B lymphocytes and follicular dendritic cells (1,2). Research studies have shown that CD21\/CR2 functions to bind the complement fragments iC3b, C3dg, and C3d, which function to activate the alternative complement pathway and MAC formation (3,4). In addition to its function as a complement receptor, CD21\/CR2 also functions as the B lymphocyte receptor for Epstein-Barr virus (5) and interferon alpha (6). Research studies have also shown that CD21\/CR2 participates in B cell activation, proliferation, and protection from apoptosis through its association with components of the B cell coreceptor signaling complex such as CD19 and CD21 (7-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nC3DR; CD21; Complement C3d receptor; complement C3d receptor 2; complement component (3d\/Epstein Barr virus) receptor 2; complement component 3d receptor 2; Complement receptor type 2; CR; CR2; CVID7; EBV receptor; Epstein-Barr virus receptor; SLEB9\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 150\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46801035657385,"sku":"98245S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-98245s","provider":"Iright","version":"1.0","type":"link"}