{"product_id":"cst-98271t","title":"CST,  98271T, DELE1 (E9K6O) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying DELE1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, DELE1 (E9K6O) Rabbit Monoclonal Antibody (CST #98271) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDELE1 (E9K6O) Rabbit Monoclonal Antibody recognizes overexpressed levels of total DELE1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human DELE1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nDAP3-binding cell death enhancer 1 (DELE1) is a protein kinase activator that responds to mitochondrial stress as part of the integrated stress response (ISR) (1-4). The OMA1-DELE1-HRI ISR pathway is activated by cellular stressors such as iron deficiency, causing OMA1 to cleave DELE1 into a short form (DELE1(S) or S-DELE1), which accumulates in the cytosol and activates the protein kinase activity of EIF2AK1\/HRI (1-4). Under stable cell conditions, DELE1 is quickly degraded (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDAP3 binding cell death enhancer 1; DAP3-binding cell death enhancer 1; DAP3-binding cell death enhancer 1 short form; DAP3-binding cell death enhancer 1, long form; Death ligand signal enhancer; DELE; Dele1; DELE1(L); DELE1(S); hypothetical protein LOC9812; K0141; KIAA0141; S-DELE1; Uncharacterized protein KIAA0141, mitochondrial\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Transfected Only\nMW (kDa): 60\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801035788457,"sku":"98271T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-98271t","provider":"Iright","version":"1.0","type":"link"}