{"product_id":"cst-98494t","title":"CST,  98494T, COMMD3 (E2X1V) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying COMMD3. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, COMMD3 (E2X1V) Rabbit Monoclonal Antibody (CST #98494) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCOMMD3 (E2X1V) Rabbit Monoclonal Antibody recognizes endogenous levels of total COMMD3 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys187 of human COMMD3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe COMMD\/CCDC93\/CCDC22 (CCC) protein complex contains any one of ten COMMD proteins. The CCC complex, which is a subcomplex of the commander complex, plays a key role in protecting the stability and promoting endosomal recycling of cell surface transmembrane proteins (1-3). Indeed, research studies have demonstrated that COMMD3 regulates endosomal trafficking of HER2 (4). In line with its roll in modulating endosomal trafficking of proteins, multiple functional genetic screens identified COMMD3 as a SARS-CoV-2 proviral host factor (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nBUP; C10orf8; COMD3; COMM domain containing 3; COMM domain-containing protein 3; COMMD3; DKFZp686K0399; FLJ45471; Protein Bup; Protein PIL\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 21\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801036968105,"sku":"98494T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-98494t","provider":"Iright","version":"1.0","type":"link"}