{"product_id":"cst-98797s","title":"CST,  98797S, IL-6R alpha\/CD126 (E5B3P) Rabbit Monoclonal Antibody (Alexa Fluor® 647 Conjugate)","description":"Monoclonal Antibody for studying IL6R. Validated for Flow Cytometry (Live). Highly specific and rigorously validated in-house, IL-6R alpha\/CD126 (E5B3P) Rabbit Monoclonal Antibody (Alexa Fluor\u003csup\u003e®\u003c\/sup\u003e 647 Conjugate) (CST #98797) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFlow Cytometry (Live): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg\/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Flow Cytometry (Live)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIL-6R alpha\/CD126 (E5B3P) Rabbit Monoclonal Antibody (Alexa Fluor\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human IL-6Rα\/CD126 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe IL-6 receptor is a heterodimeric complex that consists of a ligand-binding IL-6 receptor α (IL-6Rα) subunit and a signaling component, gp130 (1). Binding of IL-6 to IL-6Rα results in receptor dimerization with gp130 and subsequent STAT3 activation (1). IL-6Rα is cleaved from the cell surface by ADAM17 (1,2). In humans, soluble IL-6Rα is also generated via alternatively spliced mRNA (1,3). Soluble IL-6Rα binds to IL-6 and can stimulate signaling via membrane bound gp130 in a process known as \"trans-signaling\" (1). It is through trans-signaling that IL-6 stimulates cells that do not express membrane bound IL-6Rα (1).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCD126; CD126 antigen; gp80; HIES5; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-1; IL-6R-alpha; IL-6RA; IL6Q; IL6QTL; IL6R; IL6RA; IL6RQ; interleukin 6 receptor; interleukin 6 receptor alpha subunit; Interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991; sIL6R; Soluble interleukin-6 receptor subunit alpha\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800569827497,"sku":"98797S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-98797s","provider":"Iright","version":"1.0","type":"link"}