{"product_id":"cst-99086t","title":"CST,  99086T, CDC40 (E4V4J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CDC40. Validated for Western Blotting,Immunoprecipitation,eCLIP. Available in 2 sizes. Highly specific and rigorously validated in-house, CDC40 (E4V4J) Rabbit Monoclonal Antibody (CST #99086) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFor more information about the RBP-eCLIP service please visit Eclipsebio .\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\neCLIP: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCDC40 (E4V4J) Rabbit Monoclonal Antibody recognizes endogenous levels of total CDC40 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro459 of human CDC40 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCDC40\/ PRP17 (Pre-mRNA-processing factor 17) is associated with the activated spliceosome, and is required for pre-mRNA splicing. CDC40 is necessary for efficient G1\/S and G2\/M transitions, linking splicing to control of cell cycle progression (1,2).CDC40 expression is induced in hepatitis B virus (HBV)-infected hepatocellular carcinoma (HCC) cells through NF-κB and miR-1269b, promoting malignancy in HCC (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCDC40; cell division cycle 40; Cell division cycle 40 homolog; cell division cycle 40 homolog (S. cerevisiae); EH-binding protein 3; EHB3; FLJ10564; hPRP17; MGC102802; pre-mRNA splicing factor 17; Pre-mRNA-processing factor 17; PRP17; PRP17 homolog; PRPF17\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 75\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801039949993,"sku":"99086T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-99086t","provider":"Iright","version":"1.0","type":"link"}