{"product_id":"cst-99395s","title":"CST,  99395S, MBL (E2F7B) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying MBL2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, MBL (E2F7B) Rabbit Monoclonal Antibody (CST #99395) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMBL (E2F7B) Rabbit Monoclonal Antibody recognizes endogenous levels of total MBL protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln194 of human MBL protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMannose-binding lectin (MBL) is a member of the collectin family of proteins and plays a key role in innate immunity via activation of the lectin complement pathway (1). MBL is produced in the liver and circulates in the serum in complexes with MBL-associated serine proteases (MASPS) (1,2). MBL acts as a pattern recognition receptor and binds carbohydrates on the surface of various microorganisms as well as on dying host cells (3,4). In humans, only one MBL protein form is found in the serum, but in rodents, two MBL forms have been characterized, MBL-A and MBL-C (5). Polymorphisms in the MBL gene, , are associated with predisposition to myocardial infarction, pathogenesis of pulmonary tuberculosis (PTB), and three single point mutations in exon 1 are responsible for the most common human immunodeficiencies leading to increased susceptibility to infectious disease (6-8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCOLEC1; Collectin-1; HSMBPC; mannan-binding lectin; Mannan-binding protein; mannose binding lectin 2; Mannose-binding lectin; mannose-binding lectin (protein C) 2, soluble (opsonic defect); mannose-binding lectin 2, soluble (opsonic defect); Mannose-binding protein C; MBL; MBL2; MBL2D; MBP; MBP-C; MBP1; MBPD\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 30\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801041883305,"sku":"99395S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-99395s","provider":"Iright","version":"1.0","type":"link"}