{"product_id":"cst-99613s","title":"CST,  99613S, SELENBP1 (F7V8F) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SELENBP1. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, SELENBP1 (F7V8F) Rabbit Monoclonal Antibody (CST #99613) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSELENBP1 (F7V8F) Rabbit Monoclonal Antibody recognizes endogenous levels of total SELENBP1 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro15 of human SELENBP1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSelenium-binding protein 1 (SELENBP1), also known as SBP, is a widely expressed methanethiol oxidase, an enzyme capable of converting methanethiol to hydrogen sulfide, hydrogen peroxide, and formaldehyde (1). SELENBP1 is able to bind selenium, though it is not required for its enzymatic activity; copper, however, is a required cofactor (2). SELENBP1 is reported to act as a tumor suppressor; its expression is downregulated in several types of cancer, such as lung, bladder, and colorectal cancer (3-5). overexpression is associated with schizophrenia. The prefrontal cortex and blood of schizophrenia patients show elevated gene expression levels, and transgenic mice engineered to express human SELENBP1 in the frontal cortex exhibit a subset of schizophrenia-like phenotypes (6,7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n56 kDa selenium-binding protein; EHMTO; epididymis secretory sperm binding protein Li 134P; FLJ13813; HEL-S-134P; hSBP; hSP56; LPSB; Methanethiol oxidase; MTO; SBP; SBP1; SBP56; SELENBP1; selenium binding protein 1; Selenium-binding protein 1; SP56\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 52\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46801042636969,"sku":"99613S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-99613s","provider":"Iright","version":"1.0","type":"link"}