{"product_id":"cst-9996l","title":"CST,  9996L, Oligomycin","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nOligomycin is supplied as a lyophilized powder. For a 5 mM stock, reconstitute the 5 mg in 1.26 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 0.5 - 10 μM for 0.5 - 8 hours.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nDuring oxidative phosphorylation in mitochondria, the electron transport system pumps H from the matrix into the intermembrane compartment. This process generates a H gradient across the mitochondrial inner membrane. This H gradient is used to drive mitochondrial F F ATPase to convert ADP to ATP. Oligomycin, an antibiotic from , blocks oxidative phosphorylation by binding to the F part of the ATPase to inhibit its activity (1-3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nactivator; AMPK; AMPK alpha; AMPKa; AMPKalpha; oligo; oligomycin; oxidative phosporylation; stimulator","brand":"CST","offers":[{"title":"Default Title","offer_id":46800702177449,"sku":"9996L","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-9996l","provider":"Iright","version":"1.0","type":"link"}