{"product_id":"promega-j1601","title":"Promega, J1601, T Cell Activation Bioassay (NFAT\/IL-2)","description":"\u003cp\u003eMeasure Stability and Precision of Biologics Designed to Affect T Cell Responses\u003cbr\u003e\nPrequalified according to ICH guidelines\u003cbr\u003e\nAmenable to high-throughput formats\u003cbr\u003e\nSupplied in convenient thaw-and-use format; also available in cell propagation model (CPM) format\u003cbr\u003e\nSpecifications：\u003cbr\u003e\nTCR\/CD3 Effector Cells (NFAT)\tJ133A\t1 × 0.8ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t1 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t1 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t1 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t1 × 1 vial\u003cbr\u003e\nTCR\/CD3 Effector Cells (NFAT)\tJ133A\t5 × 0.8ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t5 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t5 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t5 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t5 × 1 vial\u003cbr\u003e\nTCR\/CD3 Effector Cells (CPM) (NFAT)\tJ131A\t2 × 1ml\u003cbr\u003e\nTCR\/CD3 Effector Cells (IL-2)\tJ129A\t1 × 0.8ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t1 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t1 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t1 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t1 × 1 vial\u003cbr\u003e\nTCR\/CD3 Effector Cells (IL-2)\tJ129A\t5 × 0.8ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t5 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t5 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t5 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t5 × 1 vial\u003cbr\u003e\nTCR\/CD3 Effector Cells (CPM) (IL-2)\tJ127A\t2 × 1ml\u003cbr\u003e\nImmunotherapy strategies aimed at inducing, strengthening or engineering T cell responses have emerged as promising approaches for the treatment of diseases such as cancer and autoimmunity. T cell activation is initiated by engagement of the TCR\/CD3 complex and the co-stimulatory receptor CD28, with TCR\/CD3 engagement activating the NFAT pathway and TCR\/CD3 + CD28 co-engagement activating NFAT, AP-1 and NF-κB pathways and inducing IL-2 production.\u003cbr\u003e\nThe T Cell Activation Bioassays are bioluminescent cell-based assays that overcome the limitations of existing assays and can be used for the discovery and development of novel biologics such as bispecific antibodies and CAR-T cell therapies.\u003c\/p\u003e","brand":"Promega","offers":[{"title":"Default Title","offer_id":46835631947945,"sku":"J1601","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/promega-j1601","provider":"Iright","version":"1.0","type":"link"}