{"product_id":"promega-j2172","title":"Promega, J2172, OX40 Bioassay","description":"\u003cp\u003eMeasure Potency and Stability of Biologics Designed to Activate OX40\u003cbr\u003e\nPrequalified according to ICH guidelines\u003cbr\u003e\n96- and 384-well plate formats\u003cbr\u003e\nSupplied in convenient thaw-and-use format; also available in cell propagation model (CPM) format\u003cbr\u003e\nSpecifications：\u003cbr\u003e\nOX40 Effector Cells\tJ219A\t1 × 0.5ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t1 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t1 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t1 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t1 × 1 vial\u003cbr\u003e\nOX40 Effector Cells\tJ219A\t5 × 0.5ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t5 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t5 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t5 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t5 × 1 vial\u003cbr\u003e\nOX40 Effector Cells (CPM)\tJ217A\t2 × 1ml\u003cbr\u003e\nControl Ab, Anti-OX40\tK119A\t1 × 50μg\u003cbr\u003e\nThe OX40 Bioassay is a bioluminescent cell-based assay that measures the potency and stability of ligands or agonist antibodies that can bind and activate OX40. OX40 (CD134\/TNFRSF4), a member of the tumor necrosis factor (TNF) receptor superfamily, is a costimulatory receptor expressed primarily on activated T cells, and on neutrophils and natural killer (NK) cells to a lesser extent. When present on the cell surface, OX40 interacts with OX40 ligand (OX40L) and induces subsequent cell proliferation, survival and production of cytokines, particularly in T cells.\u003cbr\u003e\nThe OX40 Bioassay reflects the mechanism of action (MOA) of biologics designed to activate OX40 following the addition of OX40 ligand or OX40 agonist antibodies.\u003cbr\u003e\nControl Ab, Anti-OX40, is a mouse anti-human OX40 agonist antibody. It can be used as a positive control in the OX40 Bioassays in the presence of FcγRIIb CHO-K1 Cells (Cat.# J2232, JA2251, JA2255).\u003c\/p\u003e","brand":"Promega","offers":[{"title":"Default Title","offer_id":46835629752489,"sku":"J2172","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/promega-j2172","provider":"Iright","version":"1.0","type":"link"}