{"product_id":"promega-j2272","title":"Promega, J2272, GITR Bioassay","description":"\u003cp\u003eMeasure Potency and Stability of Biologics Designed to Activate GITR\u003cbr\u003e\nPrequalified according to ICH guidelines\u003cbr\u003e\n96- and 384-well plate formats\u003cbr\u003e\nSupplied in convenient thaw-and-use format; also available in cell propagation model (CPM) format\u003cbr\u003e\nSpecifications：\u003cbr\u003e\nGITR Effector Cells\tJ229A\t1 × 0.5ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t1 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t1 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t1 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t1 × 1 vial\u003cbr\u003e\nGITR Effector Cells\tJ229A\t5 × 0.5ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t5 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t5 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t5 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t5 × 1 vial\u003cbr\u003e\nGITR Effector Cells (CPM)\tJ227A\t2 × 1ml\u003cbr\u003e\nControl Ab, Anti-GITR\tK117A\t1 × 50μg\u003cbr\u003e\nThe GITR Bioassays are bioluminescent cell-based assays used to measure the potency and stability of ligands or agonist antibodies that bind and activate GITR. GITR (CD357\/TNFRSF18), a member of the tumor necrosis factor (TNF) receptor superfamily, is a costimulatory receptor widely expressed on most immune cells and further upregulated on activated T cells. When engaged with GITR ligand (GITRL) on the cell surface, GITR enhances subsequent T cell expansion and cytokine production including interleukin-2 (IL-2) and IL-9.\u003cbr\u003e\nThe GITR Bioassay reflects the mechanism of action (MOA) of biologics designed to activate GITR.\u003cbr\u003e\nControl Ab, Anti-GITR, is a rabbit anti-human GITR agonist antibody. It can be used as a positive control in the GITR Bioassays (Cat.# JA2291, JA2295, J2272) in the presence of FcγRIIb CHO-K1 Cells (Cat.# J2232, JA2251, JA2255).\u003c\/p\u003e","brand":"Promega","offers":[{"title":"Default Title","offer_id":46835629621417,"sku":"J2272","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/promega-j2272","provider":"Iright","version":"1.0","type":"link"}