{"product_id":"promega-j2332","title":"Promega, J2332, 4-1BB Bioassay","description":"\u003cp\u003eA Simpler, More Consistent 4-1BB Bioassay\u003cbr\u003e\nPrequalified according to ICH guidelines\u003cbr\u003e\nMechanism-of-action (MOA)-based assay\u003cbr\u003e\nNo primary cell culture required\u003cbr\u003e\nSupplied in convenient thaw-and-use format; also available in cell propagation model (CPM) format\u003cbr\u003e\nSpecifications：\u003cbr\u003e\n4-1BB Effector Cells\tJ235A\t1 × .5ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t1 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t1 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t1 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t1 × 1 vial\u003cbr\u003e\n4-1BB Effector Cells\tJ235A\t5 × .5ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t5 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t5 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t5 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t5 × 1 vial\u003cbr\u003e\n4-1BB Effector Cells (CPM)\tJ233A\t2 × 1ml\u003cbr\u003e\nControl Ab, Anti-4-1BB\tK116A\t1 × 50μg\u003cbr\u003e\n4-1BB (CD137\/TNFRSF9), a member of the tumor necrosis factor receptor superfamily, is an inducible co-stimulatory receptor expressed on T cells, natural killer (NK) cells and innate immune cell populations. When present on the cell surface, 4-1BB interacts with 4-1BB ligand (4-1BBL) and induces subsequent cell proliferation and production of interferon gamma (IFNγ) and interleukin-2 (IL-2), particularly in T and NK cells.\u003cbr\u003e\nCurrent methods used to measure the activity of biologic drugs targeting 4-1BB rely on assays that are laborious and highly variable due to their reliance on donor primary cells, complex assay protocols and unqualified assay reagents and, as a result, are difficult to establish in a quality-controlled, drug-development setting.\u003cbr\u003e\nThe 4-1BB Bioassay is a biologically relevant, MOA-based assay that can be used to measure the potency and stability of ligands or agonist antibodies that can bind and activate 4-1BB.\u003cbr\u003e\nControl Ab, Anti-4-1BB, is a mouse anti-human 4-1BB agonist antibody. It can be used as a positive control in the 4-1BB Bioassay in the presence of FcγRIIb CHO-K1 Cells (Cat.# JA2251, JA2255).\u003c\/p\u003e","brand":"Promega","offers":[{"title":"Default Title","offer_id":46835630014633,"sku":"J2332","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/promega-j2332","provider":"Iright","version":"1.0","type":"link"}