{"product_id":"promega-j3102","title":"Promega, J3102, RANKL Bioassay","description":"\u003cp\u003eMeasure Potency and Stability of Biologics Designed to Affect RANKL Signaling\u003cbr\u003e\nPrequalified according to ICH guidelines\u003cbr\u003e\n96- and 384-well plate formats\u003cbr\u003e\nNo primary cell culture required\u003cbr\u003e\nSupplied in convenient thaw-and-use format; also available in cell propagation model (CPM) format\u003cbr\u003e\nSpecifications：\u003cbr\u003e\nRANKL Bioassay Cells (CPM)\tJ310A\t2 × 1ml\u003cbr\u003e\nRANKL Bioassay Cells\tJ312A\t1 × 0.5ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t1 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t1 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t1 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t1 × 1 vial\u003cbr\u003e\nRANKL Bioassay Cells\tJ312A\t5 × 0.5ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t5 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t5 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t5 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t5 × 1 vial\u003cbr\u003e\nReceptor activator of nuclear factor-κB (RANK\/TRANCE receptor\/TNFRSF11A) is a member of the tumor necrosis factor receptor (TNFR) family. Binding of its ligand RANKL to the receptor regulates osteoclast formation, activation and survival in bone modeling and remodeling, along with several pathologic conditions characterized by increased bone turnover.\u003cbr\u003e\nThe RANKL Bioassay is a bioluminescent cell-based assay designed to measure RANKL stimulation or inhibition. The RANKL Bioassay Cells have been engineered to express luc2P in response to RANKL signaling. When RANKL binds, the receptor transduces intracellular signals, resulting in luminescence. The bioluminescent signal is detected and quantified using Bio-Glo™ Reagent.\u003c\/p\u003e","brand":"Promega","offers":[{"title":"Default Title","offer_id":46835618545833,"sku":"J3102","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/promega-j3102","provider":"Iright","version":"1.0","type":"link"}