{"product_id":"promega-ja6705","title":"Promega, JA6705, CD28 Bioassay","description":"\u003cp\u003eMeasure Potency and Stability of Biologics Designed to Activate CD28\u003cbr\u003e\n96- and 384-well plate compatible\u003cbr\u003e\nPrequalified according to ICH guidelines\u003cbr\u003e\nNo primary cell culture required\u003cbr\u003e\nAvailable in convenient thaw-and-use format\u003cbr\u003e\nSpecifications：\u003cbr\u003e\nTCR\/CD3 Effector Cells (IL-2)\tJ129A\t1 × 0.8ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t1 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t1 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t1 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t1 × 1 vial\u003cbr\u003e\nTCR\/CD3 Effector Cells (IL-2)\tJ129A\t5 × 0.8ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t5 × 4ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t5 × 36ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Buffer\tG719A\t5 × 10ml\u003cbr\u003e\nBio-Glo™ Luciferase Assay Substrate\tG720A\t5 × 1 vial\u003cbr\u003e\nTCR\/CD3 Effector Cells (CPM) (IL-2)\tJ127A\t2 × 1ml\u003cbr\u003e\nFcγRIIb aAPC\/CHO-K1 (CPM)\tJ325A\t2 × 1ml\u003cbr\u003e\nControl Ab, Anti-CD28\tK123A\t1 × 1 each\u003cbr\u003e\nThe CD28 Bioassay is a bioluminescent cell-based assay used to measure the potency and stability of ligands or antibodies that activate CD28. CD28 binds to the B7 family members CD80 and CD86 (collectively referred to as B7 for this bioassay) on antigen-presenting cells (APCs). Co-stimulation of T cells by CD28 activation initiates signaling cascades that result in AP-1 and NFκB transcription factor activation and nuclear translocation. These pathways significantly enhance T cell cytokine production—specifically, interleukin-2 (IL-2)—which promotes T cell proliferation, differentiation and survival.\u003cbr\u003e\nAntibodies that agonize CD28 have the potential to enhance immune responses against cancer and chronic infection. The CD28 Bioassay reflects the mechanism of action (MOA) of biologics designed to activate CD28.\u003c\/p\u003e","brand":"Promega","offers":[{"title":"Default Title","offer_id":46835628572841,"sku":"JA6705","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/promega-ja6705","provider":"Iright","version":"1.0","type":"link"}