{"product_id":"promega-k1241","title":"Promega, K1241, ICOS Blockade Bioassay","description":"\u003cp\u003eMeasure Potency and Stability of Biologics Designed to Block ICOS Interactions\u003cbr\u003e\nUses Bio-Glo-NL™ Luciferase Assay System\u003cbr\u003e\nPrequalified according to ICH guidelines\u003cbr\u003e\n96- and 384-well plate compatible\u003cbr\u003e\nAvailable in convenient thaw-and-use format\u003cbr\u003e\nSpecifications：\u003cbr\u003e\nICOS Effector Cells\tJ328A\t1 × 1 vial\u003cbr\u003e\nICOSL aAPC\/CHO-K1 Cells\tJ330A\t1 × 0.5ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t1 × 4ml\u003cbr\u003e\nHam's F-12 Medium\tJ123A\t1 × 25ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t1 × 36ml\u003cbr\u003e\nBio-Glo-NL™ Luciferase Assay Buffer\tJ308A\t1 × 10ml\u003cbr\u003e\nBio-Glo-NL™ Luciferase Assay Substrate\tJ309A\t1 × 200μl\u003cbr\u003e\nICOS Effector Cells\tJ328A\t5 × 1 vial\u003cbr\u003e\nICOSL aAPC\/CHO-K1 Cells\tJ330A\t5 × 0.5ml\u003cbr\u003e\nFetal Bovine Serum\tJ121A\t5 × 4ml\u003cbr\u003e\nHam's F-12 Medium\tJ123A\t5 × 25ml\u003cbr\u003e\nRPMI 1640 Medium\tG708A\t5 × 36ml\u003cbr\u003e\nBio-Glo-NL™ Luciferase Assay Buffer\tJ308A\t5 × 10ml\u003cbr\u003e\nBio-Glo-NL™ Luciferase Assay Substrate\tJ309A\t5 × 200μl\u003cbr\u003e\nICOS Effector Cells (CPM)\tJ327A\t2 × 1ml\u003cbr\u003e\nICOSL aAPC\/CHO-K1 Cells (CPM)\tJ329A\t2 × 1ml\u003cbr\u003e\nControl Ab, Anti-ICOS\tK124A\t1 × 50μg\u003cbr\u003e\nThe ICOS Blockade Bioassay is a bioluminescent cell-based assay used to measure the potency and stability of of ligands or antibodies that bind and block ICOS\/ICOSL. ICOS (CD278) binds to its ligand ICOSL (B7-H2, CD275), which is constitutively expressed on B cells, monocytes and dendritic cells, and can be induced on endothelial and epithelial cells during inflammation. ICOS co-stimulation induces the production of effector T cell cytokines such as interferon (IFN)-γ, interleukin (IL)-4 and IL-10.\u003cbr\u003e\nThe ICOS Blockade Bioassay reflects the mechanism of action (MOA) of biologics designed to block the interaction of ICOS with its ligand, ICOSL.\u003c\/p\u003e","brand":"Promega","offers":[{"title":"Default Title","offer_id":46835629162665,"sku":"K1241","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/promega-k1241","provider":"Iright","version":"1.0","type":"link"}